Molecular docking analysis of HER-2 inhibitor from the ZINC database as anticancer agents.

ABSTRACT: The human epidermal growth factor (HER2) is a transmembrane receptor that is highly expressed in breast cancer and in different other cancers. Therefore, it is of interest to identify the new HER2 inhibitors from a selected 300 compounds in the ZINC database. The top two hit compounds (ZINC000014780728 (-11.0 kcal/mol) and ZINC000014762512 (-10.8 kcal/mol)) showed a high affinity with HER2 relative to the reference compound (lapatinib (-10.2 kcal/mol)) for further consideration.

SUBMITTER: Sait KHW 

PROVIDER: S-EPMC8573456 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature