Ontology highlight
ABSTRACT:
SUBMITTER: Christoffer C
PROVIDER: S-EPMC8574012 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Christoffer Charles C Kihara Daisuke D
Methods in molecular biology (Clifton, N.J.) 20200101
Modeling the tertiary structure of protein-protein interaction complex has been well studied over many years, especially in the case where the structures of both binding partners are roughly the same before and after binding. However, the assembly of complexes with less-ordered partners is a much harder problem, and modeling even small amounts of flexibility can pose a challenge. In an extreme case, where one of the binding partners is intrinsically disordered before binding, we have previously ...[more]