Sex differences in the expression of the endocannabinoid system within V1M cortex and PAG of Sprague Dawley rats.

ABSTRACT:

Background

Several chronic pain disorders, such as migraine and fibromyalgia, have an increased prevalence in the female population. The underlying mechanisms of this sex-biased prevalence have yet to be thoroughly documented, but could be related to endogenous differences in neuromodulators in pain networks, including the endocannabinoid system. The cellular endocannabinoid system comprises the endogenous lipid signals 2-AG (2-arachidonoylglycerol) and AEA (anandamide); the enzymes that synthesize and degrade them; and the cannabinoid receptors. The relative prevalence of different components of the endocannabinoid system in specific brain regions may alter responses to endogenous and exogenous ligands.

Methods

Brain tissue from naïve male and estrous staged female Sprague

SUBMITTER: Levine A 

PROVIDER: S-EPMC8577021 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature