Mir24-2-5p suppresses the osteogenic differentiation with Gnai3 inhibition presenting a direct target via inactivating JNK-p38 MAPK signaling axis.
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ABSTRACT:
SUBMITTER: Meng L
PROVIDER: S-EPMC8579458 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
Mir24-2-5p suppresses the osteogenic differentiation with Gnai3 inhibition presenting a direct target via inactivating JNK-p38 MAPK signaling axis.
Meng Li L Yuan Lichan L Ni Jieli J Fang Mengru M Guo Shuyu S Cai Huayang H Qin Jinwei J Cai Qi Q Zhang Mengnan M Hu Fang F Ma Junqing J Zhang Yang Y
International journal of biological sciences 20211017 15
<b>Background:</b> Congenital anomalies are increasingly becoming a global pediatric health concern, which requires immediate attention to its early diagnosis, preventive strategies, and efficient treatments. Guanine nucleotide binding protein, alpha inhibiting activity polypeptide 3 (Gnai3) gene mutation has been demonstrated to cause congenital small jaw deformity, but the functions of Gnai3 in the disease-specific microRNA (miRNA) upregulations and their downstream signaling pathways during o ...[more]
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