Optimizing Adaptive Therapy Based on the Reachability to Tumor Resistant Subpopulation.

ABSTRACT: Adaptive therapy exploits the self-organization of tumor cells to delay the outgrowth of resistant subpopulations successfully. When the tumor has aggressive resistant subpopulations, the outcome of adaptive therapy was not superior to maximum tolerated dose therapy (MTD). To explore methods to improve the adaptive therapy's performance of this case, the tumor system was constructed by osimertinib-sensitive and resistant cell lines and illustrated by the Lotka-Volterra model in this study. Restore index proposed to assess the system reachability can predict the duration of each treatment cycle. Then the threshold of the restore index was estimated to evaluate the timing of interrupting the treatment cycle and switching to high-frequency administration. The introduced reachability-based ada

SUBMITTER: Wang J 

PROVIDER: S-EPMC8582524 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature