Unknown

Dataset Information

0

Pathophysiological functions of Rnd proteins.


ABSTRACT: Rnd proteins constitute a subfamily of Rho GTPases represented in mammals by Rnd1, Rnd2 and Rnd3. Despite their GTPase structure, their specific feature is the inability to hydrolyse GTP-bound nucleotide. This aspect makes them atypical among Rho GTPases. Rnds are regulated for their expression at the transcriptional or post-transcriptional levels and they are activated through post-translational modifications and interactions with other proteins. Rnd proteins are mainly involved in the regulation of the actin cytoskeleton and cell proliferation. Whereas Rnd3 is ubiquitously expressed, Rnd1 and 2 are tissue-specific. Increasing data has described their important role during development and diseases. Herein, we describe their involvement in physiological and pathological conditions with a focus on the neuronal and vascular systems, and summarize their implications in tumorigenesis.

SUBMITTER: Basbous S 

PROVIDER: S-EPMC8583191 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC4842315 | biostudies-literature
| S-EPMC3442376 | biostudies-literature
| S-EPMC9220330 | biostudies-literature
| S-EPMC3351924 | biostudies-other
| S-EPMC7136389 | biostudies-literature
| S-EPMC5731810 | biostudies-other
| S-EPMC9160023 | biostudies-literature
| S-EPMC5645086 | biostudies-literature
| S-EPMC8863369 | biostudies-literature
| S-EPMC7375925 | biostudies-literature