Ontology highlight
ABSTRACT:
SUBMITTER: Takahashi K
PROVIDER: S-EPMC8584076 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Takahashi Kei K Nakamura Shinsuke S Shimazawa Masamitsu M Hara Hideaki H
International journal of molecular sciences 20211026 21
Progranulin (PGRN) is a secreted glycoprotein that regulates numerous cellular processes. The role of PGRN as a regulator of lysosomes has recently received attention. The purpose of this study was to characterize the retinal phenotype in mature PGRN knockout (<i>Grn</i><sup>-/-</sup>) mice. The a-wave amplitude of scotopic electroretinogram and outer nuclear thickness were significantly reduced at 6 months of age in <i>Grn<sup>-/-</sup></i> mice compared to wild-type (<i>Grn<sup>+/+</sup></i>) ...[more]