Periaqueductal gray neurons encode the sequential motor program in hunting behavior of mice.

ABSTRACT: Sequential encoding of motor programs is essential for behavior generation. However, whether it is critical for instinctive behavior is still largely unknown. Mouse hunting behavior typically contains a sequential motor program, including the prey search, chase, attack, and consumption. Here, we reveal that the neuronal activity in the lateral periaqueductal gray (LPAG) follows a sequential pattern and is time-locked to different hunting actions. Optrode recordings and photoinhibition demonstrate that LPAG^Vgat neurons are required for the prey detection, chase and attack, while LPAG^Vglut2 neurons are selectively required for the attack. Ablation of inputs that could trigger hunting, including the central amygdala, the lateral hypothalamus, and the zona incerta, interr

SUBMITTER: Yu H 

PROVIDER: S-EPMC8586038 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature