Ontology highlight
ABSTRACT:
SUBMITTER: Wright KM
PROVIDER: S-EPMC6435320 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Wright Kristina M KM McDannald Michael A MA
eLife 20190307
Faced with potential harm, individuals must estimate the probability of threat and initiate an appropriate fear response. In the prevailing view, threat probability estimates are relayed to the ventrolateral periaqueductal gray (vlPAG) to organize fear output. A straightforward prediction is that vlPAG single-unit activity reflects fear output, invariant of threat probability. We recorded vlPAG single-unit activity in male, Long Evans rats undergoing fear discrimination. Three 10 s auditory cues ...[more]