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Amide-Assisted Rearrangement of Hydroxyarylformimidoyl Chloride to Diarylurea.

ABSTRACT: A novel amide-assisted rearrangement reaction of hydroxybenzimidoyl chloride has been established for the efficient synthesis of 1,3-diphenylurea derivatives. A variety of electronically and sterically different 1,3-diphenylurea derivatives can be obtained in good to excellent yields, and a proposed reaction mechanism is also presented.

SUBMITTER: Song X

PROVIDER: S-EPMC8587945 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Amide-Assisted Rearrangement of Hydroxyarylformimidoyl Chloride to Diarylurea.

Song Xizhong X Liu Xiaoyu X Yu Wei W Jin Yi Y

Molecules (Basel, Switzerland) 20211025 21

A novel amide-assisted rearrangement reaction of hydroxybenzimidoyl chloride has been established for the efficient synthesis of 1,3-diphenylurea derivatives. A variety of electronically and sterically different 1,3-diphenylurea derivatives can be obtained in good to excellent yields, and a proposed reaction mechanism is also presented. ...[more]

PMID: 34770846

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