In vitro Antimicrobial Activity Comparison of Linezolid, Tedizolid, Sutezolid and Delpazolid Against Slowly Growing Mycobacteria Isolated in Beijing, China.

ABSTRACT:

Background

The antimicrobial activities of some new oxazolidinones against slowly growing mycobacteria (SGM) have never been well evaluated.

Methods

We evaluate the in vitro susceptibility of 20 reference strains and 157 clinical isolates, pertaining different SGM species, against four oxazolidinones, ie, delpazolid, sutezolid, tedizolid and linezolid. In addition, the association of linezolid resistance and mutations in 23srRNA, rplC, rplD were also tested.

Results

Sutezolid presented the strongest antimicrobial activity against the clinical isolates of M. intracellulare than the other oxazolidinones, with MIC₅₀ at 2 μg/mL and MIC₉₀ at 4 μg/mL. MICs of sutezolid were usually 4- to 8-fold lower than these of linezolid against M.

SUBMITTER: Yu X 

PROVIDER: S-EPMC8590452 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature