Project description:A randomised control trial was done to assess clinical and immunological benefits of passive immunization using convalescent plasma therapy (CPT), compared with standard of care, in severe COVID-19 patients presenting with acute respiratory distress syndrome (ARDS). Plasma abundance of a large panel of cytokines was quantitated before and after intervention to assess the effect of CPT on the systemic hyper-inflammation encountered in these patients. Transfused convalescent plasma was characterized in terms of its neutralizing antibody content as well as proteome. While across all age-groups clinical outcomes were not significantly different, significant immediate mitigation of hypoxia, reduction in hospital stay as well as significant survival benefit were registered in severe COVID-19 patients with ARDS aged less than 67 years receiving CPT. In addition to its neutralizing antibody content, a significant effect of the anti-inflammatory proteome of convalescent plasma on attenuation of systemic cytokine deluge, contributed to the clinical benefits of CPT.

2022-02-17 | PXD025453 | Pride

The relationship between diabetes and clinical outcomes in COVID-19: a single-center retrospective analysis.

Project description: Not available

| S-EPMC7429932 | biostudies-literature

Clinical characteristics of 14 COVID-19 deaths in Tianmen, China: a single-center retrospective study.

Project description: Not available

| S-EPMC7816151 | biostudies-literature

Post COVID-19 pulmonary complications; a single center experience.

Project description: Not available

| S-EPMC8578026 | biostudies-literature

Anticoagulation in COVID-19: a single-center retrospective study.

Project description: Not available