Ontology highlight
ABSTRACT:
SUBMITTER: Orr B
PROVIDER: S-EPMC8595644 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Orr Bernardo B De Sousa Filipe F Gomes Ana Margarida AM Afonso Olga O Ferreira Luísa T LT Figueiredo Ana C AC Maiato Helder H
Cell reports 20211101 6
Micronuclei are a hallmark of cancer and several other human disorders. Recently, micronuclei were implicated in chromothripsis, a series of massive genomic rearrangements that may drive tumor evolution and progression. Here, we show that Aurora B kinase mediates a surveillance mechanism that integrates error correction during anaphase with spatial control of nuclear envelope reassembly to prevent micronuclei formation. Using high-resolution live-cell imaging of human cancer and non-cancer cells ...[more]