Death Pathways of Cancer Cells Modulated by Surface Molecule Density on Gold Nanorods.

ABSTRACT: Necrosis induces strong inflammation with undesirable implications in clinics compared with apoptosis. Fortunately, the switch between necrosis and apoptosis could be realized by tailoring the appropriate structural properties of gold nano rods (GNRs) that could precisely modulate cell death pathways. Herein, the intracellular interaction between GNRs and organelles is monitored and it is found that lysosomes dominates necrosis/apoptosis evoking. Then the surface molecule density of GNRs, which is first defined as ρ_{surf. molecule} (N_{surf. molecules} /(a × π × Diameter × Length)), mediates lysosome activities as the membrane permeabilization (LMP), the Cathepsin B and D release, the cross-talk between lysosome and different organelles, which selectively evokes apoptosis

SUBMITTER: Zhang F 

PROVIDER: S-EPMC8596106 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature