Patient-Derived Organoids Can Guide Personalized-Therapies for Patients with Advanced Breast Cancer.
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ABSTRACT:
SUBMITTER: Chen P
PROVIDER: S-EPMC8596108 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Publications
Patient-Derived Organoids Can Guide Personalized-Therapies for Patients with Advanced Breast Cancer.
Chen Ping P Zhang Xu X Ding Renbo R Yang Linglin L Lyu Xueying X Zeng Jianming J Lei Josh Haipeng JH Wang Lijian L Bi Jiong J Shao Nan N Shu Ditian D Wu Bin B Wu Jingbo J Yang Zhihui Z Wang Haiyan H Wang Biqiong B Xiong Kang K Lu Yun Y Fu Shaozhi S Choi Tak Kan TK Lon Ng Wai NW Zhang Aiping A Tang Dongyang D Quan Yingyao Y Meng Ya Y Miao Kai K Sun Heng H Zhao Ming M Bao Jiaolin J Zhang Lei L Xu Xiaoling X Shi Yanxia Y Lin Ying Y Deng Chuxia C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20211004 22
Most breast cancers at an advanced stage exhibit an aggressive nature, and there is a lack of effective anticancer options. Herein, the development of patient-derived organoids (PDOs) is described as a real-time platform to explore the feasibility of tailored treatment for refractory breast cancers. PDOs are successfully generated from breast cancer tissues, including heavily treated specimens. The microtubule-targeting drug-sensitive response signatures of PDOs predict improved distant relapse- ...[more]
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