Unknown

Dataset Information

0

Genetically Engineered Polypeptide Adhesive Coacervates for Surgical Applications.


ABSTRACT: Adhesive hydrogels have been developed for wound healing applications. However, their adhesive performance is impaired dramatically due to their high swelling on wet tissues. To tackle this challenge, we fabricated a new type of non-swelling protein adhesive for underwater and in vivo applications. In this soft material, the electrostatic complexation between supercharged polypeptides with oppositely charged surfactants containing 3,4-dihydroxylphenylalanine or azobenzene moieties plays an important role for the formation of ultra-strong adhesive coacervates. Remarkably, the adhesion capability is superior to commercial cyanoacrylate when tested in ambient conditions. Moreover, the adhesion is stronger than other reported protein-based adhesives in underwater environment. The ex vivo and in vivo experiments demonstrate the persistent adhesive performance and outstanding behaviors for wound sealing and healing.

SUBMITTER: Sun J 

PROVIDER: S-EPMC8596419 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC3083470 | biostudies-literature
| S-EPMC6982730 | biostudies-literature
| S-EPMC9597652 | biostudies-literature
| S-EPMC3196066 | biostudies-literature
| S-EPMC11374812 | biostudies-literature
| S-EPMC3419450 | biostudies-other
| S-EPMC7153322 | biostudies-literature
| S-EPMC9325888 | biostudies-literature
| S-EPMC6195910 | biostudies-literature
| S-EPMC5528413 | biostudies-other