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Alkyne Aminopalladation/Heck and Suzuki Cascades: An Approach to Tetrasubstituted Enamines.

ABSTRACT: Alkyne aminopalladation reactions starting from tosylamides are reported. The emerging vinylic Pd species are converted either in an intramolecular Heck reaction with olefinic units or in an intermolecular Suzuki reaction by using boronic acids exhibiting broad functional group tolerance. Tetra(hetero)substituted tosylated enamines are obtained in a simple one-pot process.

SUBMITTER: Geffers FJ

PROVIDER: S-EPMC8596888 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Alkyne Aminopalladation/Heck and Suzuki Cascades: An Approach to Tetrasubstituted Enamines.

Geffers Finn J FJ Kurth Florens R FR Jones Peter G PG Werz Daniel B DB

Chemistry (Weinheim an der Bergstrasse, Germany) 20211014 60

Alkyne aminopalladation reactions starting from tosylamides are reported. The emerging vinylic Pd species are converted either in an intramolecular Heck reaction with olefinic units or in an intermolecular Suzuki reaction by using boronic acids exhibiting broad functional group tolerance. Tetra(hetero)substituted tosylated enamines are obtained in a simple one-pot process. ...[more]

PMID: 34611939

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