Accurate Localization of Linear Probe Electrode Arrays across Multiple Brains.

ABSTRACT: Recently developed probes for extracellular electrophysiological recordings have large numbers of electrodes on long linear shanks. Linear electrode arrays, such as Neuropixels probes, have hundreds of recording electrodes distributed over linear shanks that span several millimeters. Because of the length of the probes, linear probe recordings in rodents usually cover multiple brain areas. Typical studies collate recordings across several recording sessions and animals. Neurons recorded in different sessions and animals thus have to be aligned to each other and to a standardized brain coordinate system. Here, we evaluate two typical workflows for localization of individual electrodes in standardized coordinates. These workflows rely on imaging brains with fluorescent probe tracks and warpi

SUBMITTER: Liu LD 

PROVIDER: S-EPMC8597948 | biostudies-literature | 2021 Nov-Dec

REPOSITORIES: biostudies-literature