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The lungfish cocoon is a living tissue with antimicrobial functions.


ABSTRACT: [Figure: see text].

SUBMITTER: Heimroth RD 

PROVIDER: S-EPMC8597997 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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The lungfish cocoon is a living tissue with antimicrobial functions.

Heimroth Ryan Darby RD   Casadei Elisa E   Benedicenti Ottavia O   Amemiya Chris Tsuyoshi CT   Muñoz Pilar P   Salinas Irene I  

Science advances 20211117 47


Terrestrialization is an extreme physiological adaptation by which African lungfish survive dry seasons. For months and up to several years, lungfish live inside a dry mucus cocoon that protects them from desiccation. Light and electron microscopy reveal that the lungfish cocoon is a living tissue that traps bacteria. Transcriptomic analyses identify a global state of inflammation in the terrestrialized lungfish skin characterized by granulocyte recruitment. Recruited granulocytes transmigrate i  ...[more]

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