Quantitative cross-species translators of cardiac myocyte electrophysiology: Model training, experimental validation, and applications.
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ABSTRACT:
SUBMITTER: Morotti S
PROVIDER: S-EPMC8598003 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Publications
Quantitative cross-species translators of cardiac myocyte electrophysiology: Model training, experimental validation, and applications.
Morotti Stefano S Liu Caroline C Hegyi Bence B Ni Haibo H Fogli Iseppe Alex A Wang Lianguo L Pritoni Marco M Ripplinger Crystal M CM Bers Donald M DM Edwards Andrew G AG Grandi Eleonora E
Science advances 20211117 47
Animal experimentation is key in the evaluation of cardiac efficacy and safety of novel therapeutic compounds. However, interspecies differences in the mechanisms regulating excitation-contraction coupling can limit the translation of experimental findings from animal models to human physiology and undermine the assessment of drugs’ efficacy and safety. Here, we built a suite of translators for quantitatively mapping electrophysiological responses in ventricular myocytes across species. We train ...[more]
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