Dataset Information

Precision medicine for patients with gastro-oesophageal cancer: A subset analysis of the ProfiLER program.

ABSTRACT:

Background

Chemotherapy, anti-HER2 and PD-1 antibodies are standard treatments but only a minority of patients derive long-term benefit from these agents.

Methods

In this report we describe the mutational landscape and outcome of patients with gastroesophageal cancers enroled in the ProfiLER program.

Results

Adenocarcinoma (n = 86, 59%), signet-cell (n = 37, 25%) and squamous-cell (n = 21, 14%) were the dominant histology amongst 147 patients. Genomic analyses could be performed for 114 (78%) patients. The most common genomic alterations involved ERBB2 (15%), KRAS (12%), CCND1 (7%), FGFR1-3 (8%), EGFR (5%) and MET (3%), TP53 (51%) and CDKN2A/B (10%). ERBB2, MET and FGFR alterations were found exclusively in the adenocarcinoma and signet-cell subtypes, while CCND1 amplification, TP53 mutations and CDKN2A/B loss were found in both adenocarcinoma and squamous-cell subtypes. Nine patients (8%) received therapy matched to their genomic alteration, with 5 of them achieving disease control. In an exploratory analysis, patients with stage IV disease at diagnosis who had an actionable alteration had longer overall survival compared to those without.

Conclusion

Genomic profiling for patients with advanced gastroesophageal cancers allows the identification of actionable alterations in large proportion of patients. Increased accessibility to molecularly matched therapy may improve survival in this disease.

SUBMITTER: Cassier PA

PROVIDER: S-EPMC8605190 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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Publications

Precision medicine for patients with gastro-oesophageal cancer: A subset analysis of the ProfiLER program.

Cassier Philippe A PA Peyramaure Clémentine C Attignon Valery V Eberst Lauriane L Pacaud Camille C Boyault Sandrine S Desseigne Françoise F Sarabi Mathieu M Guibert Pierre P Rochefort Pauline P Marques Nathalie N Rivoire Michel M Dupré Aurélien A Peyrat Patrice P Terret Catherine C Ray-Coquard Isabelle I Coutzac Clélia C Pérol David D Blay Jean-Yves JY Trédan Olivier O de la Fouchardière Christelle C

Translational oncology 20211115 1

<h4>Background</h4>Chemotherapy, anti-HER2 and PD-1 antibodies are standard treatments but only a minority of patients derive long-term benefit from these agents.<h4>Methods</h4>In this report we describe the mutational landscape and outcome of patients with gastroesophageal cancers enroled in the ProfiLER program.<h4>Results</h4>Adenocarcinoma (n = 86, 59%), signet-cell (n = 37, 25%) and squamous-cell (n = 21, 14%) were the dominant histology amongst 147 patients. Genomic analyses could be perf ...[more]

PMID: 34794033

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Project description:Background18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging (18F-FDG PET/MRI) may improve cancer staging by combining sensitive cancer detection with high-contrast resolution and detail. We compared the diagnostic performance of 18F-FDG PET/MRI to 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) for staging oesophageal/gastro-oesophageal cancer. Following ethical approval and informed consent, participants with newly diagnosed primary oesophageal/gastro-oesophageal cancer were enrolled. Exclusions included prior/concurrent malignancy. Following 324 ± 28 MBq 18F-FDG administration and 60-min uptake, PET/CT was performed, immediately followed by integrated PET/MRI from skull base to mid-thigh. PET/CT was interpreted by two dual-accredited nuclear medicine physicians and PET/MRI by a dual-accredited nuclear medicine physician/radiologist and cancer radiologist in consensus. Per-participant staging was compared with the tumour board consensus staging using the McNemar test, with statistical significance at 5%.ResultsOut of 26 participants, 22 (20 males; mean ± SD age 68.8 ± 8.7 years) completed 18F-FDG PET/CT and PET/MRI. Compared to the tumour board, the primary tumour was staged concordantly in 55% (12/22) with PET/MRI and 36% (8/22) with PET/CT; the nodal stage was concordant in 45% (10/22) with PET/MRI and 50% (11/22) with PET/CT. There was no statistical difference in PET/CT and PET/MRI staging performance (p > 0.05, for T and N staging). The staging of distant metastases was concordant with the tumour board in 95% (21/22) with both PET/MRI and PET/CT. Of participants with distant metastatic disease, PET/MRI detected additional metastases in 30% (3/10).ConclusionIn this preliminary study, compared to 18F-FDG PET/CT, 18F-FDG PET/MRI showed non-significant higher concordance with T-staging, but no difference with N or M-staging. Additional metastases detected by 18F-FDG PET/MRI may be of additive clinical value.

Dataset Information

Precision medicine for patients with gastro-oesophageal cancer: A subset analysis of the ProfiLER program.

Background

Methods

Results

Conclusion

Publications

Precision medicine for patients with gastro-oesophageal cancer: A subset analysis of the ProfiLER program.

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