Unknown

Dataset Information

0

Paper-Based Multiplexed Colorimetric Device for the Simultaneous Detection of Salivary Biomarkers.


ABSTRACT: In this study, we describe a monolithic and fully integrated paper-based device for the simultaneous detection of three prognostic biomarkers in saliva. The pattern of the proposed multiplexed device is designed with a central sample deposition zone and three identical arms, each containing a pre-treatment and test zone. Its one-step fabrication is realized by CO2 laser cutting, providing remarkable parallelization and rapidity (ca. 5 s/device). The colorimetric detection is based on the sensitive and selective target-induced reshaping of plasmonic multibranched gold nanoparticles, which exhibit a clear spectral shift (and blue-to-pink color change) in case of non-physiological concentrations of the three salivary biomarkers. A rapid and multiplexed naked-eye or smartphone-based readout of the colorimetric response is achieved within 10 min. A prototype kit for POCT testing is also reported, providing robustness and easy handling of the device.

SUBMITTER: Pomili T 

PROVIDER: S-EPMC8615519 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC7294414 | biostudies-literature
| S-EPMC7178251 | biostudies-literature
| S-EPMC7700338 | biostudies-literature
| S-EPMC4470859 | biostudies-literature
| S-EPMC8659705 | biostudies-literature
| S-EPMC9408953 | biostudies-literature
| S-EPMC9050516 | biostudies-literature
| S-EPMC4995402 | biostudies-literature
| S-EPMC10463273 | biostudies-literature
| S-EPMC7766257 | biostudies-literature