Sleep Disruption Worsens Seizures: Neuroinflammation as a Potential Mechanistic Link.

ABSTRACT: Sleep disturbances, such as insomnia, obstructive sleep apnea, and daytime sleepiness, are common in people diagnosed with epilepsy. These disturbances can be attributed to nocturnal seizures, psychosocial factors, and/or the use of anti-epileptic drugs with sleep-modifying side effects. Epilepsy patients with poor sleep quality have intensified seizure frequency and disease progression compared to their well-rested counterparts. A better understanding of the complex relationship between sleep and epilepsy is needed, since approximately 20% of seizures and more than 90% of sudden unexpected deaths in epilepsy occur during sleep. Emerging studies suggest that neuroinflammation, (e.g., the CNS immune response characterized by the change in expression of inflammatory mediators and glial activ

SUBMITTER: Bonilla-Jaime H 

PROVIDER: S-EPMC8617844 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature