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Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link.

ABSTRACT: Chronic neuroinflammation is a common feature of the aged brain, and its association with the major neurodegenerative changes involved in cognitive impairment and motor dysfunction is well established. One of the most potent antiaging interventions tested so far is dietary restriction (DR), which extends the lifespan in various organisms. Microglia and astrocytes are two major types of glial cells involved in the regulation of neuroinflammation. Accumulating evidence suggests that the age-related proinflammatory activation of astrocytes and microglia is attenuated under DR. However, the molecular mechanisms underlying DR-mediated regulation of neuroinflammation are not well understood. Here, we review the current understanding of the effects of DR on neuroinflammation and suggest an underlying mechanistic link between DR and neuroinflammation that may provide novel insights into the role of DR in aging and age-associated brain disorders.

SUBMITTER: Bok E

PROVIDER: S-EPMC6386998 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link.

Bok Eugene E Jo Myungjin M Lee Shinrye S Lee Bo-Ram BR Kim Jaekwang J Kim Hyung-Jun HJ

International journal of molecular sciences 20190122 3

Chronic neuroinflammation is a common feature of the aged brain, and its association with the major neurodegenerative changes involved in cognitive impairment and motor dysfunction is well established. One of the most potent antiaging interventions tested so far is dietary restriction (DR), which extends the lifespan in various organisms. Microglia and astrocytes are two major types of glial cells involved in the regulation of neuroinflammation. Accumulating evidence suggests that the age-relate ...[more]

PMID: 30678217

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