Mucus threads from surface goblet cells clear particles from the airways.

ABSTRACT:

Background

The mucociliary clearance system driven by beating cilia protects the airways from inhaled microbes and particles. Large particles are cleared by mucus bundles made in submucosal glands by parallel linear polymers of the MUC5B mucins. However, the structural organization and function of the mucus generated in surface goblet cells are poorly understood.

Methods

The origin and characteristics of different mucus structures were studied on live tissue explants from newborn wild-type (WT), cystic fibrosis transmembrane conductance regulator (CFTR) deficient (CF) piglets and weaned pig airways using video microscopy, Airyscan imaging and electron microscopy. Bronchoscopy was performed in juvenile pigs in vivo.

Results

We have identified a distinct mucus formation

SUBMITTER: Ermund A 

PROVIDER: S-EPMC8620232 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature