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Direct Photoexcitation of Benzothiazolines: Acyl Radical Generation and Application to Access Heterocycles.

ABSTRACT: An acyl radical generation and functionalization strategy through direct photoexcitation of benzothiazolines has been developed. The formed acyl radical species can either be trapped by quinoxalin-2-ones to realize their C(3)-H functionalization or trigger a cascade radical cyclization with isonitriles to synthesise biologically important phenanthridines. The synthetic value of this protocol can be further illustrated by the modification of quinoxalin-2-ones, containing important natural products and drug-based complex molecules.

SUBMITTER: He XK

PROVIDER: S-EPMC8624417 | biostudies-literature |

REPOSITORIES: biostudies-literature

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