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A pyrone remodeling strategy to access diverse heterocycles: application to the synthesis of fascaplysin natural products.


ABSTRACT: The synthesis of diverse N-fused heterocycles, including the pyrido[1,2-a]indole scaffold, using an efficient pyrone remodeling strategy is described. The pyrido[1,2-a]indole core was demonstrated to be a versatile scaffold that can be site-selectively functionalized. The utility of this novel annulation strategy was showcased in a concise formal synthesis of three fascaplysin congeners.

SUBMITTER: Palani V 

PROVIDER: S-EPMC8179101 | biostudies-literature |

REPOSITORIES: biostudies-literature

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