Correlation of dried blood spots and plasma for quantification of Immunoglobulin (IgG) against Receptor binding domain and full length spike protein of SARS-CoV-2.
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ABSTRACT:
SUBMITTER: Kwatra G
PROVIDER: S-EPMC8631068 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
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Correlation of dried blood spots and plasma for quantification of Immunoglobulin (IgG) against Receptor binding domain and full length spike protein of SARS-CoV-2.
Kwatra Gaurav G Nunes Marta M Dhar Nisha N Baillie Vicky V Serafin Natali N Jones Stephanie S Madhi Shabir A SA
Journal of virological methods 20211130
We compared plasma and dried blood spots for detection of SARS-CoV-2 IgG antibodies. There was a good correlation between IgG values measured by both sampling methods, r = 0.935 and 0.965 for Receptor Binding Domain and full-length spike protein of SARS-CoV-2. Bland-Altman assessment showed good agreement between two sampling methods. Dried blood spots is a more pragmatic method for collecting samples for sero-epidemiological surveys of SARS-CoV-2 infection. ...[more]
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