Mt-Keima detects PINK1-PRKN mitophagy in vivo with greater sensitivity than mito-QC.
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ABSTRACT:
SUBMITTER: Liu YT
PROVIDER: S-EPMC8632312 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Publications
Mt-Keima detects PINK1-PRKN mitophagy <i>in vivo</i> with greater sensitivity than mito-QC.
Liu Yi-Ting YT Sliter Danielle A DA Shammas Mario K MK Huang Xiaoping X Wang Chunxin C Calvelli Hannah H Maric Dragan S DS Narendra Derek P DP
Autophagy 20210308 11
PINK1 and PRKN, which cause Parkinson disease when mutated, form a quality control mitophagy pathway that is well-characterized in cultured cells. The extent to which the PINK1-PRKN pathway contributes to mitophagy <i>in vivo</i>, however, is controversial. This is due in large part to conflicting results from studies using one of two mitophagy reporters: mt-Keima or mito-QC. Studies using mt-Keima have generally detected PINK1-PRKN mitophagy <i>in vivo</i>, whereas those using mito-QC generally ...[more]
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