A Hypoxia-Associated Prognostic Gene Signature Risk Model and Prognosis Predictors in Gliomas.

ABSTRACT: Most solid tumours are hypoxic. Tumour cell proliferation and metabolism accelerate oxygen consumption. The low oxygen supply due to vascular abnormalisation and the high oxygen demand of tumour cells give rise to an imbalance, resulting in tumour hypoxia. Hypoxia alters cellular behaviour and is associated with extracellular matrix remodelling, enhanced tumour migration, and metastatic behaviour. In light of the foregoing, more research on the progressive and prognostic impacts of hypoxia on gliomas are crucial. In this study, we analysed the expression levels of 75 hypoxia-related genes in gliomas and found that a total of 26 genes were differentially expressed in The Cancer Genome Atlas (TCGA) database samples. We also constructed protein-protein interaction networks using the STRING da

SUBMITTER: Gao F 

PROVIDER: S-EPMC8632947 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature