Ontology highlight
ABSTRACT:
SUBMITTER: Kerstan A
PROVIDER: S-EPMC8635035 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Kerstan Andreas A Dieter Kathrin K Niebergall-Roth Elke E Dachtler Ann-Kathrin AK Kraft Korinna K Stücker Markus M Daeschlein Georg G Jünger Michael M Görge Tobias T Meyer-Pannwitt Ulrich U Erfurt-Berge Cornelia C von Engelhardt Charlotte C Klare Andreas A Pfeiffer Christiane C Esterlechner Jasmina J Schröder Hannes M HM Gasser Martin M Waaga-Gasser Ana M AM Goebeler Matthias M Ballikaya Seda S Sadeghi Samar S Murphy George F GF Orgill Dennis P DP Frank Natasha Y NY Ganss Christoph C Scharffetter-Kochanek Karin K Frank Markus H MH Kluth Mark A MA
JID innovations : skin science from molecules to population health 20211025 1
A significant number of chronic venous ulcers (CVUs) fail to heal despite of guideline-conform standard of care. Skin-derived ABCB5<sup>+</sup> mesenchymal stem cells (MSCs) can dampen the sustained IL-1β-driven inflammation present in chronic wounds. Based on their wound healing-facilitating effects in a mouse CVU model and an autologous first-in-human study, ABCB5<sup>+</sup> MSCs have emerged as a potential candidate for cell-based advanced therapy of non-healing CVUs. In the present interven ...[more]