Ontology highlight
ABSTRACT:
SUBMITTER: Katayama K
PROVIDER: S-EPMC8635417 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Katayama Kota K Suzuki Kohei K Suno Ryoji R Kise Ryoji R Tsujimoto Hirokazu H Iwata So S Inoue Asuka A Kobayashi Takuya T Kandori Hideki H
Communications biology 20211123 1
The intrinsic efficacy of ligand binding to G protein-coupled receptors (GPCRs) reflects the ability of the ligand to differentially activate its receptor to cause a physiological effect. Here we use attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy to examine the ligand-dependent conformational changes in the human M<sub>2</sub> muscarinic acetylcholine receptor (M<sub>2</sub>R). We show that different ligands affect conformational alteration appearing at the C=O st ...[more]