Ontology highlight
ABSTRACT:
SUBMITTER: An J
PROVIDER: S-EPMC8643665 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
An Jiao J Yin Mengdie M Yin Jiayong J Wu Sizhong S Selby Christopher P CP Yang Yanyan Y Sancar Aziz A Xu Guo-Liang GL Qian Maoxiang M Hu Jinchuan J
Nucleic acids research 20211201 21
8-Oxo-7,8-dihydro-2'-deoxyguanosine (OG), one of the most common oxidative DNA damages, causes genome instability and is associated with cancer, neurological diseases and aging. In addition, OG and its repair intermediates can regulate gene transcription, and thus play a role in sensing cellular oxidative stress. However, the lack of methods to precisely map OG has hindered the study of its biological roles. Here, we developed a single-nucleotide resolution OG-sequencing method, named CLAPS-seq ...[more]