Effects of a high-phosphorus diet on the gut microbiota in CKD rats.

ABSTRACT:

Objective

To investigate whether high-phosphorus diets alter gut microbiota in healthy rats and chronic kidney disease (CKD) rats.

Methods

In this 4-week randomized controlled trial, healthy rats and CKD rats were fed a regular-phosphorus (Pi: 0.8%) and high-phosphorus (Pi: 1.2%) diet. The subjects were divided into four groups: sham-group rats with regular-phosphorus diet intervention (CTL group), sham-group rats with high-phosphorus diet intervention (CTLP group), CKD model rats with regular-phosphorus diet intervention (CKD group), and CKD model rats with high-phosphorus diet intervention (CKDP group). The V3-V4 region of the 16S rRNA gene was sequenced to study the effect of a high-phosphorus diet on gut microbiota.

Results

A high-phosphorus intervention increased

SUBMITTER: Ye G 

PROVIDER: S-EPMC8648004 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature