Metal-Free Solvent Promoted Oxidation of Benzylic Secondary Amines to Nitrones with H2O2.
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ABSTRACT: An environmentally benign protocol for the generation of nitrones from benzylic secondary amines via catalyst-free oxidation of secondary amines using H2O2 in MeOH or CH3CN is described. This methodology provides a selective access to a variety of C-aryl nitrones in yields of 60 to 93%. Several studies have been performed to shed light on the reaction mechanism and the role of the solvent.
SUBMITTER: Granato AS
PROVIDER: S-EPMC8650016 | biostudies-literature |
REPOSITORIES: biostudies-literature
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