Dried blood spot specimens for SARS-CoV-2 antibody testing: A multi-site, multi-assay comparison.

ABSTRACT: The true severity of infection due to COVID-19 is under-represented because it is based on only those who are tested. Although nucleic acid amplifications tests (NAAT) are the gold standard for COVID-19 diagnostic testing, serological assays provide better population-level SARS-CoV-2 prevalence estimates. Implementing large sero-surveys present several logistical challenges within Canada due its unique geography including rural and remote communities. Dried blood spot (DBS) sampling is a practical solution but comparative performance data on SARS-CoV-2 serological tests using DBS is currently lacking. Here we present test performance data from a well-characterized SARS-CoV-2 DBS panel sent to laboratories across Canada representing 10 commercial and 2 in-house developed tests for SARS-CoV-

SUBMITTER: Cholette F 

PROVIDER: S-EPMC8651133 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature