Unknown

Dataset Information

0

Verification of Coronary Computed Tomography-Derived Fractional Flow Reserve Measurement Site for Detection of Significant Coronary Artery Disease.


ABSTRACT: Background: The optimal site for measuring computed tomography (CT)-derived fractional flow reserve (FFRCT) to detect significant coronary artery disease (CAD) remains unknown. We investigated how diagnostic performance changes with FFRCT measurement site. Methods and Results: The diagnostic performance of FFRCT, measured 1-2 cm distal to the stenosis vs. a far-distal site, in detecting significant CAD with invasive fractional flow reserve ≤0.8 was evaluated in 254 diseased vessels from 146 patients with stable or suspected CAD diagnosed by coronary CT angiography. Receiver operating characteristic curve analysis revealed a significantly larger area under the curve for FFRCT measured 1-2 cm distal to the stenosis than at a far-distal site (0.829 vs. 0.791, respectively; P=0.0305). The rate of reclassification of positive FFRCT was 19% for measurements made 1-2 cm distal to the stenosis, and diagnostic accuracy for FFRCT 0.71-0.80 improved from 36% to 58% (P=0.0052). Vessel-based diagnostic accuracy of FFRCT 1-2 cm distal to the stenosis and at a far-distal site was 75% and 65%, respectively (P<0.0001), with corresponding sensitivity of 87% and 94% (P=0.0039), specificity of 60% and 29% (P<0.0001), a positive predictive value of 73% and 62% (P=0.028), and a negative predictive value of 78% and 79% (P=0.958). Conclusions: Our data suggest measuring FFRCT 1-2 cm distal to the stenosis has better diagnostic performance for detecting physiologically significant CAD.

SUBMITTER: Kawasaki T 

PROVIDER: S-EPMC8651465 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

Verification of Coronary Computed Tomography-Derived Fractional Flow Reserve Measurement Site for Detection of Significant Coronary Artery Disease.

Kawasaki Tomohiro T   Okonogi Taichi T   Koga Hisashi H   Orita Yoshiya Y   Umeji Kyoko K   Fukuoka Ryota R   Hirai Keisuke K   Haraguchi Kazuki K   Kajiyama Kimihiro K   Fukami Yurie Y   Soejima Toshiya T   Abe Kensho K   Yamabe Hiroshige H  

Circulation reports 20211029 12


<b><i>Background:</i></b> The optimal site for measuring computed tomography (CT)-derived fractional flow reserve (FFR<sub>CT</sub>) to detect significant coronary artery disease (CAD) remains unknown. We investigated how diagnostic performance changes with FFR<sub>CT</sub> measurement site. <b><i>Methods and Results:</i></b> The diagnostic performance of FFR<sub>CT</sub>, measured 1-2 cm distal to the stenosis vs. a far-distal site, in detecting significant CAD with invasive fractional flow res  ...[more]

Similar Datasets

| S-EPMC5716947 | biostudies-literature
| S-EPMC9234158 | biostudies-literature
| S-EPMC4751165 | biostudies-literature
| S-EPMC6553476 | biostudies-literature
| S-EPMC8174353 | biostudies-literature
| S-EPMC5808503 | biostudies-literature
| S-EPMC7074264 | biostudies-literature
| S-EPMC6070545 | biostudies-literature
| S-EPMC4830909 | biostudies-literature
| S-EPMC6992438 | biostudies-literature