Increased proliferation is associated with CNS invasion in meningiomas.

ABSTRACT:

Introduction

Meningiomas are the most common benign intracranial neoplasms. CNS invasion in meningiomas has been integrated into the 2016 WHO classification of CNS tumors as a stand-alone criterion for atypia. Since then, its prognostic impact has been debated based on contradictory results from retrospective analyses. The aim of the study was to elucidate whether histopathological evidence of CNS invasion is associated with increased proliferative potential.

Methods

We have conducted a quantified measurement of the proliferation marker Ki67 and analyzed its association with CNS invasion determined by histology together with other established prognostic markers of progression. Routine, immunohistochemical staining for Ki67 were digitalized and automatic quantification was do

SUBMITTER: Behling F 

PROVIDER: S-EPMC8651603 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature