Direct synthesis and applications of solid silylzinc reagents.

ABSTRACT: The increased synthetic utility of organosilanes has motivated researchers to develop milder and more practical synthetic methods. Silylzinc reagents, which are typically the most functional group tolerant, are notoriously difficult to synthesize because they are obtained by a pyrophoric reaction of silyllithium, particularly Me₃SiLi which is itself prepared by the reaction of MeLi and disilane. Furthermore, the dissolved LiCl in silylzinc may have a detrimental effect. A synthetic method that can avoid silyllithium and involves a direct synthesis of silylzinc reagents from silyl halides is arguably the simplest and most economical strategy. We describe, for the first time, the direct synthesis of PhMe₂SiZnI and Me₃SiZnI reagents by employing a coordinating

SUBMITTER: Chandrasekaran R 

PROVIDER: S-EPMC8654096 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature