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Synthesis of solid 2-pyridylzinc reagents and their application in Negishi reactions.

ABSTRACT: In search of alternatives to unstable or unreliable 2-pyridylboron reagents, we have explored two new varieties of solid, moderately air-stable 2-pyridylzinc reagents. Both reagents can be manipulated in air and are competent nucleophiles in Negishi cross-coupling reactions.

SUBMITTER: Colombe JR

PROVIDER: S-EPMC3869385 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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Synthesis of solid 2-pyridylzinc reagents and their application in Negishi reactions.

Colombe James R JR Bernhardt Sebastian S Stathakis Christos C Buchwald Stephen L SL Knochel Paul P

Organic letters 20131024 22

In search of alternatives to unstable or unreliable 2-pyridylboron reagents, we have explored two new varieties of solid, moderately air-stable 2-pyridylzinc reagents. Both reagents can be manipulated in air and are competent nucleophiles in Negishi cross-coupling reactions. ...[more]

PMID: 24156393

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