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Zidovudine enhances activity of carbapenems against NDM-1-producing Enterobacteriaceae.

ABSTRACT:

Objectives

To investigate the efficacy of zidovudine in combination with carbapenems against NDM-1-producing Enterobacteriaceae.

Methods

MICs were determined using the broth microdilution method. The combinatory effects of zidovudine and carbapenems were examined using the chequerboard method and time-kill analysis.

Results

We found that the NDM-1-producing strains were resistant to all carbapenems tested. FIC index from chequerboard assay demonstrated that zidovudine synergized with carbapenems against all the NDM-1 strains. Time-kill analysis demonstrated significant synergistic activity when a low level of zidovudine was combined with meropenem.

Conclusions

Zidovudine in combination with carbapenems produced synergistic activity against NDM-1 Enterobacteriaceae strains in vitro.

SUBMITTER: Hu Y

PROVIDER: S-EPMC8654596 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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Zidovudine enhances activity of carbapenems against NDM-1-producing Enterobacteriaceae.

Hu Yanmin Y Coates Anthony A

The Journal of antimicrobial chemotherapy 20210801 9

<h4>Objectives</h4>To investigate the efficacy of zidovudine in combination with carbapenems against NDM-1-producing Enterobacteriaceae.<h4>Methods</h4>MICs were determined using the broth microdilution method. The combinatory effects of zidovudine and carbapenems were examined using the chequerboard method and time-kill analysis.<h4>Results</h4>We found that the NDM-1-producing strains were resistant to all carbapenems tested. FIC index from chequerboard assay demonstrated that zidovudine syner ...[more]

PMID: 34120178

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