Zidovudine enhances activity of carbapenems against NDM-1-producing Enterobacteriaceae.

ABSTRACT:

Objectives

To investigate the efficacy of zidovudine in combination with carbapenems against NDM-1-producing Enterobacteriaceae.

Methods

MICs were determined using the broth microdilution method. The combinatory effects of zidovudine and carbapenems were examined using the chequerboard method and time-kill analysis.

Results

We found that the NDM-1-producing strains were resistant to all carbapenems tested. FIC index from chequerboard assay demonstrated that zidovudine synergized with carbapenems against all the NDM-1 strains. Time-kill analysis demonstrated significant synergistic activity when a low level of zidovudine was combined with meropenem.

Conclusions

Zidovudine in combination with carbapenems produced synergistic activity against NDM-1 Enterobacteriaceae strains in vitro.

SUBMITTER: Hu Y 

PROVIDER: S-EPMC8654596 | biostudies-literature |

REPOSITORIES: biostudies-literature