Dataset Information

In Vitro Activity Comparison of Ceftazidime-Avibactam and Aztreonam-Avibactam Against Bloodstream Infections With Carbapenem-Resistant Organisms in China.

ABSTRACT:

Objectives

The aim of this work was to investigate the activity of ceftazidime-avibactam (CZA) and aztreonam-avibactam (AZA) against bloodstream infections caused by carbapenem-resistant organisms (CROs).

Methods

Non-duplicate CROs, including 56 carbapenem-resistant Escherichia coli (CR-Eco), 318 carbapenem-resistant Klebsiella pneumoniae (CR-Kpn), and 65 carbapenem-resistant Pseudomonas aeruginosa (CR-Pae), were collected using the Blood Bacterial Resistant Investigation Collaborative System (BRICS) program in China. The minimum inhibitory concentrations (MICs) of 24 antibiotics were tested. Carbapenemase genes were amplified for CZA-resistant CROs by PCR. The MICs of CZA and AZA were further determined with avibactam at 8 and 16 mg/L, respectively.

Results

The resistance rate of polymyxin B against CROs was less than 5%. Only one CR-Kpn was resistant to tigecycline. The resistance rates of CZA against CR-Eco, CR-Kpn, and CR-Pae were 75.0%, 12.6%, and 18.5%, respectively. The MIC₉₀ values of AZA against CR-Eco, CR-Kpn, and CR-Pae were 2/4, 1/4, and 64/4 mg/L, respectively. Among the CZA-resistant CROs, 42 (100%) CR-Eco, 24 (60%) CR-Kpn, and 1 (8.3%) CR-Pae isolates harbored metallo-β-lactamase genes. The increase of avibactam concentration enhanced the susceptibility of CZA and AZA against CROs, especially for CR-Eco and CR-Kpn.

Conclusions

The in vitro activity of AZA was superior to that of CZA against CR-Eco and CR-Kpn, whereas CZA showed better effect against CR-Pae.

SUBMITTER: Yu W

PROVIDER: S-EPMC8656719 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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<i>In Vitro</i> Activity Comparison of Ceftazidime-Avibactam and Aztreonam-Avibactam Against Bloodstream Infections With Carbapenem-Resistant Organisms in China.

Yu Wei W Xiong Luying L Luo Qixia Q Chen Yunbo Y Ji Jinru J Ying Chaoqun C Liu Zhiying Z Xiao Yonghong Y

Frontiers in cellular and infection microbiology 20211125

<h4>Objectives</h4>The aim of this work was to investigate the activity of ceftazidime-avibactam (CZA) and aztreonam-avibactam (AZA) against bloodstream infections caused by carbapenem-resistant organisms (CROs).<h4>Methods</h4>Non-duplicate CROs, including 56 carbapenem-resistant <i>Escherichia coli</i> (CR-Eco), 318 carbapenem-resistant <i>Klebsiella pneumoniae</i> (CR-Kpn), and 65 carbapenem-resistant <i>Pseudomonas aeruginosa</i> (CR-Pae), were collected using the Blood Bacterial Resistant I ...[more]

PMID: 34900759

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