Clinical Response to Anti-CD47 Immunotherapy Is Associated with Rapid Reduction of Exhausted Bystander CD4⁺ BTLA⁺ T Cells in Tumor Microenvironment of Mycosis Fungoides.

ABSTRACT: Cancer progression in mycosis fungoides, the most common form of cutaneous T-cell lymphoma, occurs in a predictable, sequential pattern that starts from patches and that evolves to plaques and later to tumors. Therefore, unlocking the relationship between the microarchitecture of mycosis fungoides and the clinical counterparts of that microstructure represents important steps for the design of targeted therapies. Using multispectral fluorescent imaging, we show that the progression of mycosis fungoides from plaque to tumor parallels the cutaneous expansion of the malignant CD4⁺ T cells that express TOX. The density of exhausted BTLA⁺ CD4⁺ T cells around malignant CD4⁺TOX⁺ cells was higher in tumors than it was in plaques, suggesting th

SUBMITTER: Jiang TT 

PROVIDER: S-EPMC8656720 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature