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Emerging Role of TCA Cycle-Related Enzymes in Human Diseases.

ABSTRACT: The tricarboxylic acid (TCA) cycle is the main source of cellular energy and participates in many metabolic pathways in cells. Recent reports indicate that dysfunction of TCA cycle-related enzymes causes human diseases, such as neurometabolic disorders and tumors, have attracted increasing interest in their unexplained roles. The diseases which develop as a consequence of loss or dysfunction of TCA cycle-related enzymes are distinct, suggesting that each enzyme has a unique function. This review aims to provide a comprehensive overview of the relationship between each TCA cycle-related enzyme and human diseases. We also discuss their functions in the context of both mitochondrial and extra-mitochondrial (or cytoplasmic) enzymes.

SUBMITTER: Kang W

PROVIDER: S-EPMC8657694 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Emerging Role of TCA Cycle-Related Enzymes in Human Diseases.

Kang Woojin W Suzuki Miki M Saito Takako T Miyado Kenji K

International journal of molecular sciences 20211202 23

The tricarboxylic acid (TCA) cycle is the main source of cellular energy and participates in many metabolic pathways in cells. Recent reports indicate that dysfunction of TCA cycle-related enzymes causes human diseases, such as neurometabolic disorders and tumors, have attracted increasing interest in their unexplained roles. The diseases which develop as a consequence of loss or dysfunction of TCA cycle-related enzymes are distinct, suggesting that each enzyme has a unique function. This review ...[more]

PMID: 34884868

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