Unknown

Dataset Information

0

Yellow fever vaccination in Brazil: Short-term safety and immunogenicity in juvenile autoimmune rheumatic diseases.


ABSTRACT: Yellow fever vaccine (YFV) is a live attenuated vaccine usually contraindicated for juvenile autoimmune rheumatic disease (JARD) patients. During the recent epidemic in Sao Paulo-Brazil, YFV was indicated for patients under low immunosuppression. Thirty JARD patients with inactive diseases undergoing low immunosuppression and 30 healthy controls (HC) were vaccinated with a fractional dose 17DD YFV (∼5495 IU) and evaluated 30 days later. JARD patients and controls had comparable median age (12.4 vs. 12 years, p = 0.250). Disease parameters remained stable 30 days after 17DD YFV (p > 0.05) and only mild adverse events were reported in both groups (p > 0.05). JARD and HC had similar seroprotection [93% vs. 100%;p = 0.49], seroconversion rates [96% vs. 100%;p = 0.489], and GMT [1249 vs.1293;p = 0.821]. Both groups had similar white-blood-cells kinetics with transient decreases in lymphocytes at D5 and neutrophils at D10, followed by full recovery at D30 (P < 0.05). In conclusion, 17DD YFV was safe and immunogenic in JARD. This study may contribute to recommendations for patients living/travelling to endemic areas.

SUBMITTER: Emi Aikawa N 

PROVIDER: S-EPMC8686021 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC8659329 | biostudies-literature
| S-EPMC8153874 | biostudies-literature
| S-EPMC8128885 | biostudies-literature
| S-EPMC10131534 | biostudies-literature
| S-EPMC9111021 | biostudies-literature
| S-EPMC7906671 | biostudies-literature
| S-EPMC9874440 | biostudies-literature
| S-EPMC9527375 | biostudies-literature
| S-EPMC9666508 | biostudies-literature