Genome-wide methylation and expression analyses reveal the epigenetic landscape of immune-related diseases for tobacco smoking.

ABSTRACT:

Background

Smoking is a major causal risk factor for lung cancer, chronic obstructive pulmonary disease (COPD), cardiovascular disease (CVD), and is the main preventable cause of deaths in the world. The components of cigarette smoke are involved in immune and inflammatory processes, which may increase the prevalence of cigarette smoke-related diseases. However, the underlying molecular mechanisms linking smoking and diseases have not been well explored. This study was aimed to depict a global map of DNA methylation and gene expression changes induced by tobacco smoking and to explore the molecular mechanisms between smoking and human diseases through whole-genome bisulfite sequencing (WGBS) and RNA-sequencing (RNA-seq).

Results

We performed WGBS on 72 samples (36 smokers an

SUBMITTER: Mao Y 

PROVIDER: S-EPMC8662854 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature