Positive End-Expiratory Pressure and Respiratory Rate Modify the Association of Mechanical Power and Driving Pressure With Mortality Among Patients With Acute Respiratory Distress Syndrome.

ABSTRACT:

Importance

Mechanical power and driving pressure have known associations with survival for patients with acute respiratory distress syndrome.

Objectives

To further understand the relative importance of mechanical power and driving pressure as clinical targets for ventilator management.

Design

Secondary observational analysis of randomized clinical trial data.

Setting and participants

Patients with the acute respiratory distress syndrome from three Acute Respiratory Distress Syndrome Network trials.

Main outcomes and measures

After adjusting for patient severity in a multivariate Cox proportional hazards model, we examined the relative association of driving pressure and mechanical power with hospital mortality. Among 2,410 patients, the relationship betw

SUBMITTER: Tonna JE 

PROVIDER: S-EPMC8663805 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature