Mechanical oscillations orchestrate axial patterning through Wnt activation in Hydra.
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ABSTRACT:
SUBMITTER: Ferenc J
PROVIDER: S-EPMC8664257 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Publications
Mechanical oscillations orchestrate axial patterning through Wnt activation in <i>Hydra</i>.
Ferenc Jaroslav J Papasaikas Panagiotis P Ferralli Jacqueline J Nakamura Yukio Y Smallwood Sebastien S Tsiairis Charisios D CD
Science advances 20211210 50
Mechanical input shapes cell fate decisions during development and regeneration in many systems, yet the mechanisms of this cross-talk are often unclear. In regenerating <i>Hydra</i> tissue spheroids, periodic osmotically driven inflation and deflation cycles generate mechanical stimuli in the form of tissue stretching. Here, we demonstrate that tissue stretching during inflation is important for the appearance of the head organizer—a group of cells that secrete the Wnt3 ligand. Exploiting time ...[more]
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