Ontology highlight
ABSTRACT:
SUBMITTER: Abutaleb NS
PROVIDER: S-EPMC8667909 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Abutaleb Nader S NS Elhassanny Ahmed E M AEM Nocentini Alessio A Hewitt Chad S CS Elkashif Ahmed A Cooper Bruce R BR Supuran Claudiu T CT Seleem Mohamed N MN Flaherty Daniel P DP
Journal of enzyme inhibition and medicinal chemistry 20221201 1
<i>Neisseria gonorrhoeae</i> is a high-priority pathogen of concern due to the growing prevalence of resistance development against approved antibiotics. Herein, we report the anti-gonococcal activity of ethoxzolamide, the FDA-approved human carbonic anhydrase inhibitor. Ethoxzolamide displayed an MIC<sub>50,</sub> against a panel of <i>N. gonorrhoeae</i> isolates, of 0.125 µg/mL, 16-fold more potent than acetazolamide, although both molecules exhibited almost similar potency against the gonococ ...[more]