Ontology highlight
ABSTRACT:
SUBMITTER: She W
PROVIDER: S-EPMC8669609 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
She Wenting W Shao Jun J Jia Rong R
Frontiers in cell and developmental biology 20211130
Aberrant alternative splicing of pre-mRNA is an emerging cancer hallmark. Many cancer-associated genes undergo alternative splicing to produce multiple isoforms with diverse or even antagonistic functions. Oncogenic isoforms are often up-regulated, whereas tumor suppressive isoforms are down-regulated during tumorigenesis. Serine/arginine-rich splicing factor 6 (SRSF6) is an important splicing factor that regulates the alternative splicing of hundreds of target genes, including many cancer-assoc ...[more]